| Bioactivity | Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) generates lipid-based ROS and induce ferroptosis |
| Invitro | Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) 在BJAB、NALM-6、Jurkat、MelHO和MCF-7癌细胞中表现出抗肿瘤活性 (IC50s 值分别为0.07、2.5、1.5、3和5 µM)。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) 相关抗体: |
| CAS | 39916-28-4 |
| Formula | C20H14ClFeN2O2 |
| Molar Mass | 405.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jessica Sagasser, et al. A New Approach in Cancer Treatment: Discovery of Chlorido[ N, N'-disalicylidene-1,2-phenylenediamine]iron(III) Complexes as Ferroptosis Inducers. J Med Chem. 2019 Sep 12;62(17):8053-8061. [2]. Soo-Young Lee, et al. [FeIII (salophene) Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells. Leukemia Research 35 (2011) 387-393. |